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MED 122 · Biochemistry

جامعة العلوم والتكنولوجيا الأردنية · السنة الأولى · ٣ ساعات معتمدة

موقعها في الخطة الاسترشادية ٢٠٢٣: السنة الأولى، الفصل الثاني

وصف المادة (من الجامعة)

This general biochemistry course tailored for first-year medical students delves into the intricate molecular foundations governing life processes. From elucidating the building blocks of life, such as carbohydrates, lipids, and proteins, to exploring the dynamic metabolic pathways essential for cellular function, the course navigates through the complexities of biochemical reactions. Emphasizing the integration of molecular principles with clinical contexts, it highlights the role of biochemistry in understanding disease mechanisms and therapeutic interventions. Through theoretical learning and practical applications, students acquire the knowledge necessary to comprehend the biochemical foundations that govern health and disease in clinical practice.

كيف تُحسب علامة المادة في الجامعة

مساقات السنة الأولى وبداية الثانية والمساقات النظرية، للطلبة المقبولين من ٢٠١٨/٢٠١٩

  • ٥٥٪اختباران فصليان (٢٧٫٥ علامة لكل منهما)
  • ٥٪الانضباط والسلوك والمواظبة
  • ٤٠٪الامتحان النهائي
تعليمات العلامات والامتحانات في كلية الطب

مواضيع المادة بالترتيب (من خطة المادة)

  1. Prelude to biochemistry. Acids and bases, buffers, Henderson-Hasselbalch equation
  2. Amino acids and proteins I: Structure and classification of amino acids. Properties of individual amino acids and their titration curves
  3. Amino acids and proteins II: Peptide bond, proteins primary, secondary, super secondary, tertiary (domains) and quaternary (subunits) structure. Protein folding. Protein denaturation and refolding
  4. Enzymes I: Enzymes as biological catalysts, classification of enzymes, properties, how they work. Enzyme active site. Chymotrypsin as example on how enzymes work
  5. Enzymes II: Factors affecting their activity. Kinetics; Michaelis-Menten equation, Lineweaver- Burke plot. Coenzymes. Enzymes inhibition and regulation
  6. Bioenergetics and Oxidative Phosphorylation. Thermodynamics of metabolic reactions and ATP molecule as a carrier of energy
  7. Introduction to Carbohydrates
  8. Glycolysis: Glucose transport into the cells. Aerobic and anaerobic glycolysis. Enzymes involve in glycolysis. Key steps in glycolysis and their regulation
  9. Tricarboxylic Acid Cycle and Pyruvate Dehydrogenase Complex. Metabolism of pyruvate and the tricarboxylic acid cycle
  10. Gluconeogenesis and the Cori cycle: Key steps, enzymes involve and their regulation
  11. Glycogen Metabolism
  12. Monosaccharide and Disaccharide Metabolism
  13. Pentose Phosphate Pathway and Nicotinamide Adenine Dinucleotide Phosphate
  14. Dietary Lipid Metabolism: Lipids and Fatty acids: Structure, nomenclature, properties and sources of fatty acids. Essential fatty acids
  15. Fatty acids digestion and absorption. Fatty acid synthesis and beta-oxidation
  16. Phospholipid, Glycosphingolipid, and Eicosanoid Metabolism
  17. Amino Acids I: Nitrogen Disposal
  18. Amino Acids II: Degradation and Synthesis
  19. Metabolic Effects of Insulin and Glucagon
  20. The Feed- Fast Cycle
  21. Micronutrients: Vitamins
  22. Basics of signal transduction

ماذا تقيس المادة، ووزن كل جزء

  • 10%Students will be able to analyze buffer systems to predict pH changes and interpret amino acid titration curves accurately
  • 10%Students will be able to relate enzyme structure, function, and kinetics to predict enzymatic reactions and interpret regulatory mechanisms.
  • 15%Students will be able to recall the fundamental structures of biomolecules such as proteins, lipids, and carbohydrates.
  • 45%Students will be able to analyze the diverse metabolic pathways of biomolecules, demonstrating an understanding of their interconnections, regulation, and the role of enzymes in catalyzing these processes within biological systems.
  • 10%Students will be able to interpret how insulin, glucagon, and metabolic pathways interact in the feed-fast cycle.
  • 5%Students will be able to describe the roles of vitamins in metabolic processes and their significance in maintaining cellular functions.
  • 5%Students will be able to examine how signal transduction pathways integrate into cellular responses to external stimuli.

الكتاب المقرر

  • Lippincott Illustrated Reviews: Biochemistry, Denise Ferrier (7th Edition)

الخطة التفصيلية للمادة على موقع الجامعة · صادرة الفصل الثاني ٢٠٢٢/٢٠٢٣

مواد ذات صلة في السنة الأولى