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MED 202 · الوراثة

السنة 2 · 22 محاضرة · 3 ساعات معتمدة

العناوين والأهداف منقولة من خطة كلية الطب الرسمية.

موقعها في الخطة الاسترشادية 2023: السنة الثانية، الفصل الأول

وصف المساق (من الجامعة)

The Genetics course (MED202) is designed for second-year medical students, offering an in-depth understanding of molecular genetics. This comprehensive exploration covers the intricate structure, regulation of gene expression, genetic mutations, and polymorphisms. Students gain systematic exposure to essential tools used in molecular biology for studying these complex processes. Additionally, the curriculum thoroughly examines primary cytogenetic techniques, emphasizing their clinical significance in diagnosing chromosomal abnormalities. The course extends its focus to a thorough examination of Mendelian inheritance patterns of single-gene disorders. Moreover, it offers insightful insights into the biochemical regulation of the cell cycle and cell death, while extensively discussing the genetic and molecular basis of cancer. Throughout the course, pertinent clinical correlations are seamlessly integrated, reinforcing the practical application of theoretical knowledge.

كيف تُحسب علامة المساق في الجامعة

مساقات السنة الأولى وبداية الثانية والمساقات النظرية، للطلبة المقبولين من 2018/2019

  • ٥٥٪اختباران فصليان (٢٧٫٥ علامة لكل منهما)
  • ٥٪الانضباط والسلوك والمواظبة
  • ٤٠٪الامتحان النهائي
تعليمات العلامات والامتحانات في كلية الطب

ماذا يقيس المساق، ووزن كل جزء

  • 24%Students will be able to implement the central dogma of biochemistry, proficiently outlining the mechanisms that regulate the flow of genetic information from DNA to RNA to protein, and their interconnection in transmitting and utilizing genetic information.
  • 5%Students will be able to describe how gene expression is regulated at the transcriptional and post-transcriptional level
  • 14%Students will be able to apply molecular techniques like PCR, DNA sequencing, and genetic engineering methods as well as artificial intelligence to analyze and manipulate genetic material.
  • 9%Students will be able to proficiently differentiate the biochemical regulation of the cell cycle, apoptosis pathways, oncogenes, tumor suppressor genes, and key characteristics of cancer cells.
  • 9%Students will be able to apply cytogenetic principles, including chromosomal structure and karyotyping techniques, to identify diverse chromosomal anomalies.
  • 9%Students will be able to apply Mendelian inheritance rules to explain patterns of genetic transmission, including autosomal and sex-linked traits.
  • 30%Students will be able to analyze nucleotide structures, the organization of nucleic acids, and the molecular processes of DNA replication, recombination, repair, and mutation.

الكتاب المقرر

  • Textbook of Biochemistry with Clinical Correlations, Thomas M. Devlin (8th Edition)

الخطة التفصيلية للمساق على موقع الجامعة · صادرة الفصل الأول 2025/2026

مواد ذات صلة في السنة الثانية

هذه الوحدة في جامعتك

المحاضرات وأهدافها

  1. 1. Purine metabolism

    Molecular Genetics

    • Recognise and contrast the structures of the purines.
    • Contrast the salvage and de novo pathways of purine synthesis.
    • Understand the steps of purine synthesis, including the enzymes and their regulation.
    • Understand the steps of purine degradation.
    • Recognise how dysregulation of purine metabolism contributes to disease.

  2. 2. Pyrimidine metabolism

    Molecular Genetics

    • Recognise and contrast the structures of the pyrimidines.
    • Understand the steps of pyrimidine synthesis, including the enzymes and their regulation.
    • Understand the steps of pyrimidine degradation.

  3. 3. Structure of nucleic acids I

    Molecular Genetics

    • Understand the structure of nucleotides and how they are organised into nucleic acids.
    • Understand the experiments that led to the discovery of the structure of DNA.
    • Understand the structure of the DNA double helix.

  4. 4. Structure of nucleic acids II

    Molecular Genetics

    • Understand the differences in chromatin structure between prokaryotes and eukaryotes, including the role of nucleosomes.
    • Differentiate DNA from RNA structure.
    • Differentiate the structures of rRNA, mRNA, tRNA and miRNA.

  5. 5. DNA replication I

    Molecular Genetics

    • Understand the central dogma and the differences between replication, transcription and translation.
    • Understand the importance of DNA replication in cell division.
    • Differentiate the conservative, semiconservative and dispersive models of replication.
    • Understand the experiments that established semiconservative replication.

  6. 6. DNA replication II

    Molecular Genetics

    • Understand the mechanism of DNA replication and the roles of its key proteins and enzymes.
    • Differentiate replication in prokaryotes and eukaryotes.
    • Understand the function of telomerase.

  7. 7. Mutations, DNA repair and recombination I

    Molecular Genetics

    • Understand the definition of mutation.
    • Compare the different types of mutations.

  8. 8. Mutations, DNA repair and recombination II

    Molecular Genetics

    • Compare the DNA repair pathways: mismatch repair, base excision repair and nucleotide excision repair.
    • Describe recombination and how it happens.

  9. 9. Transcription in prokaryotes

    Molecular Genetics

    • Understand transcription in prokaryotes and the roles of its key proteins and enzymes.
    • Write the sequence of an RNA molecule from a DNA template.

  10. 10. Transcription in eukaryotes

    Molecular Genetics

    • Understand transcription in eukaryotes and the roles of its key proteins and enzymes.
    • Compare transcription in prokaryotes and eukaryotes.

  11. 11. RNA processing

    Molecular Genetics

    • Understand the importance of RNA processing in establishing genetic diversity in eukaryotes.
    • Understand the mechanism and function of 5' capping, RNA editing, polyadenylation and splicing.

  12. 12. Regulation of gene expression in prokaryotes

    Molecular Genetics

    • Understand the structure and regulation of the lac operon.
    • Understand the structure and regulation of the tryptophan operon and its attenuation model.

  13. 13. Regulation of transcription in eukaryotes

    Molecular Genetics

    • Understand the role of histone acetylation in regulating transcription.
    • Understand the structure of eukaryotic promoters and enhancers.
    • Study nuclear receptors as an example of eukaryotic transcriptional regulation.

  14. 14. Translation in prokaryotes

    Molecular Genetics

    • Understand protein synthesis in prokaryotes and the roles of its key proteins and enzymes.
    • Appreciate the effects of antibiotics on prokaryotic protein synthesis.

  15. 15. Translation in eukaryotes

    Molecular Genetics

    • Understand protein synthesis in eukaryotes and the roles of its key proteins and enzymes.
    • Compare protein synthesis in prokaryotes and eukaryotes.

  16. 16. Protein processing and targeting

    Molecular Genetics

    • List the types of post-translational modification.
    • Understand the endomembrane system and the sorting of cellular proteins.
    • Understand the role of ubiquitination in protein degradation.

  17. 17. Recombinant DNA techniques

    Molecular Genetics

    • Understand molecular cloning, gel electrophoresis, Southern, northern and western blotting.
    • Understand PCR, cDNA synthesis and Sanger sequencing.

  18. 18. Cell signalling and signal transduction

    Molecular Genetics

    • Compare endocrine, paracrine and autocrine signalling.
    • Differentiate cell-surface and nuclear receptors and compare the types of cell-surface receptors.
    • Understand the GPCR, RAF–MEK–ERK, JAK–STAT, TGF-beta–SMAD and PI3K–AKT pathways.

  19. 19. The molecular biology of cancer

    Molecular Genetics

    • Understand the normal cell division cycle.
    • Understand apoptosis and differentiate its intrinsic and extrinsic pathways.
    • Differentiate oncogenes from tumour suppressor genes.
    • Study the properties of cancer cells.

  20. 20. Inheritance

    Molecular Genetics

    • Understand the Mendelian rules of inheritance.
    • Understand autosomal dominant and recessive, sex-linked dominant and recessive, codominant and incompletely dominant inheritance, and X-inactivation.

  21. 21. Epigenetics and chromosomal karyotyping

    Molecular Genetics

    • Understand how gene expression is silenced or activated by DNA methylation, histone modification and histone variants.
    • Understand how karyotyping is performed and its applications in diagnosis.

  22. 22. Chromosomal anomalies

    Molecular Genetics

    • Understand the cause and features of Down, Edwards, Patau, Klinefelter, triple X and Turner syndromes.
    • Understand the cause and features of Angelman and Prader–Willi syndromes.

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