MED 251 · علم الأدوية العام
السنة 2 · 23 محاضرة · 3 ساعات معتمدة
العناوين والأهداف منقولة من خطة كلية الطب الرسمية.
موقعها في الخطة الاسترشادية 2023: السنة الثانية، الفصل الأول
وصف المساق (من الجامعة)
This is a general pharmacology module for second year medical students. In this series of lectures, students will be introduced to the fundamental concepts of Pharmacology including pharmacokinetics, pharmacodynamics, drug metabolism, toxicology, and drug interactions. In addition, the course will introduce students to the pharmacology of the central and autonomic nervous systems. Students will also be introduced to the major drug classes that are used to treat diseases of the cardiovascular system. This course will provide an introduction to the pharmacology and clinical use of antibiotic drugs used in the treatment of infectious diseases. Additional lectures will also cover drugs used in chemotherapy and the treatment of cancer. Other topics will include drugs used for pain management. This course will include key applications of artificial intelligence (AI) in Antimicrobial Agents and Drug Resistance, Cancer Chemotherapy and Targeted Therapy, Drug Interactions and Toxicology, as well as Drug Discovery and Clinical Trials. Students will learn how AI helps predict resistance patterns, optimize cancer treatments, identify potential drug interactions and toxicities, and accelerate drug development processes and clinical trial designs. This integration will provide a modern perspective on pharmacology and prepare students for AI-driven advances in pharmacology research and clinical care.
كيف تُحسب علامة المساق في الجامعة
مساقات السنة الأولى وبداية الثانية والمساقات النظرية، للطلبة المقبولين من 2018/2019
- ٥٥٪اختباران فصليان (٢٧٫٥ علامة لكل منهما)
- ٥٪الانضباط والسلوك والمواظبة
- ٤٠٪الامتحان النهائي
ماذا يقيس المساق، ووزن كل جزء
- 10%Recognize basic principles of Pharmacology at both branches of pharmacokinetics and pharmacodynamics.
- 20%Define the general principles of CNS and CVS pharmacology and identify the pharmacology of medications target sympathetic and parasympathetic nervous systems.
- 35%Describe the pharmacology, mechanisms of action and clinical outcomes of different types of antimicrobials such as antibacterial, antifungal, and antiviral drugs. Explain how AI Final exam models predict antimicrobial resistance and support personalized antimicrobial treatment strategies.
- 9%Describe the pharmacological targets of prostaglandin analogues and the clinical relevance of their inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs).
- 8%Summarize basic principles of drug-drug interactions and drug poisoning, and indicate best management in such cases. Introduce students to AI-based methods for predicting drug interactions and assessing toxicological risks, highlighting their potential to improve drug safety and pharmacovigilance.
- 9%Describe the pharmacology, mechanisms of action and clinical outcomes of different types of anticancer drugs including conventional cytotoxic drugs and molecular therapeutic agents. Describe AI approaches for identifying molecular targets and optimizing patient-specific cancer therapies.
- 9%Describe the traditional drug discovery process and clinical trials stages, and explain how artificial intelligence (AI) accelerates drug development and improves clinical trial design and outcomes.
الكتاب المقرر
- Goodman and Gilman?s: The Pharmacological basis of therapeutics, 13th edition, 2018. McGraw-Hill., Goodman and Gilman (13th Edition)
الخطة التفصيلية للمساق على موقع الجامعة · صادرة الفصل الأول 2025/2026
مواد ذات صلة في السنة الثانية
هذه الوحدة في جامعتك
المحاضرات وأهدافها
1. General Pharmacology I (pharmacokinetics)
Pharmacology
- Define pharmacology and its branches: pharmacognosy, pharmacokinetics, pharmacodynamics, pharmacotherapeutics and toxicology.
- Introduce the principles of pharmacokinetic parameters: absorption, distribution, metabolism and elimination.
2. General Pharmacology II (pharmacokinetics)
Pharmacology
- Describe the physicochemical and physiological factors that influence drug absorption by enteral and parenteral routes, distribution, metabolism and elimination.
- Explain how dose, bioavailability, rate of absorption, apparent volume of distribution, total clearance and elimination half-life affect plasma drug concentration.
3. General Pharmacology III (drug–receptor interactions and pharmacodynamics)
Pharmacology
- Understand what is meant by pharmacodynamics.
- Describe what is meant by a cell receptor and the concept of receptor occupancy, with examples of receptors.
- Outline how drugs affect the body and the dose–response relationship.
- Define affinity, potency, efficacy and therapeutic index.
- Differentiate a drug that is an agonist from one that is an antagonist.
- Use basic arithmetic to calculate simple drug dosages.
4. Antimicrobial Agents I (principles of antimicrobial therapy)
Pharmacology
- Know the principles of antimicrobial therapy.
- Know the classification of antimicrobial agents.
- Define narrow and broad spectrum, superinfection, bacteriostatic, bactericidal, empiric therapy and prophylactic therapy.
- Know the advantages and disadvantages of antibiotic combinations.
5. Antimicrobial Agents II (cell wall synthesis inhibitors 1)
Pharmacology
- Know the mechanisms of action, indications, adverse effects, contraindications, cautions and relative safety in pregnancy and children of antibacterial agents.
- List the beta-lactam and non-beta-lactam drugs.
6. Antimicrobial Agents III (cell wall synthesis inhibitors 2)
Pharmacology
- Know the mechanism of action of penicillins and cephalosporins, their clinical uses, adverse effects and contraindications.
7. Antimicrobial Agents IV (protein synthesis inhibitors)
Pharmacology
- List the drugs that inhibit protein synthesis, their actions, clinical uses, contraindications and adverse effects.
8. Antimicrobial Agents V (nucleic acid synthesis inhibitors)
Pharmacology
- List the drugs that inhibit bacterial DNA synthesis, their actions, clinical uses, contraindications and adverse effects.
9. Antimicrobial Agents VI (folic acid antagonists and new antimicrobial drugs)
Pharmacology
- Know the main mechanism of action of folic acid antagonists, their clinical use, contraindications and adverse effects.
- Introduction to new antimicrobial drugs.
10. Antifungal agents
Pharmacology
- Understand the relationship between fungal structure and the mechanisms of action of antifungal drugs.
- Outline the indications, adverse effects and contraindications of ketoconazole, fluconazole and nystatin.
11. Antiprotozoal and anthelmintic agents
Pharmacology
- Understand the major therapeutic options for malaria, their mechanisms, indications and adverse effects.
- Understand combination therapy in the treatment of malaria.
- List the major therapeutic options for the worms commonly encountered in Jordan.
- Understand the major mechanisms of action of anthelmintic drugs.
12. Antiviral agents
Pharmacology
- Relate the viral life cycle to the mechanisms of action of antiviral drugs.
- Outline the indications, adverse effects and contraindications of amantadine, oseltamivir and acyclovir.
13. Introduction to CNS pharmacology
Pharmacology
- Revise the action potential and its importance in neuronal signalling.
- Discuss the neurotransmitters of the brain and their functions.
- Describe the life cycle of acetylcholine and norepinephrine.
- Describe the types of drug mechanism at each step of neurotransmission, with drug class examples.
- Differentiate agonists, antagonists, inverse agonists and biased agonists.
14. Pharmacology of the autonomic nervous system I
Pharmacology
- Identify the similarities and differences between autonomic cholinergic and adrenergic pathways: receptor subtypes, neurotransmitters, transmitter synthesis, storage and release, and the relative specificity of drugs acting on each.
15. Pharmacology of the autonomic nervous system II
Pharmacology
- List the major systems and organs innervated by the cholinergic and adrenergic systems.
- Describe the organ system effects of cholinergic and adrenergic stimulation and antagonism.
16. Pharmacology of the autonomic nervous system III
Pharmacology
- Relate the tissue expression of cholinergic and adrenergic receptors to their specific functions.
17. Introduction to CVS pharmacology
Pharmacology
- Understand the major physiological mechanisms regulating cardiac and vascular function.
- Understand chronotropy, dromotropy, inotropy and lusitropy.
- Understand the role of the renin–angiotensin–aldosterone system in blood pressure regulation.
- Describe the major pharmacological strategies for hypertension and ischaemic heart disease.
18. Management of drug poisoning
Pharmacology
- Understand the concept of drug poisoning.
- Give examples of common toxidromes.
- Understand the term antidote.
- Outline the major strategies in the emergency treatment of common drug poisonings.
19. Drug interactions, drug evaluation and clinical trials
Pharmacology
- Understand drug–drug interactions and their pharmacological basis.
- List common drug interactions in clinical practice.
- Outline strategies to prevent and reverse drug interactions.
- Describe the process of drug discovery from the laboratory to the market.
- Outline the major strategies in the evaluation of new drugs.
- Understand clinical trials: their phases, requirements and regulation.
20. Autacoids
Pharmacology
- Understand the concept of autacoids and their functions in the body.
- Know the properties and effects of histamine.
- Know the histamine receptors and their locations.
- Identify the types of histamine antagonists, their clinical uses and adverse effects.
21. NSAIDs
Pharmacology
- Understand prostanoid biosynthesis and list the therapeutic uses of prostaglandins.
- Understand the mechanism of action, chemical classes, therapeutic uses and side effects of NSAIDs.
- Compare the classes of NSAIDs and recognise the therapeutic differences of aspirin and acetaminophen.
22. Principles of antineoplastic agents I
Pharmacology
- Discuss the principles of conventional cytotoxic cancer chemotherapy.
- Understand the pharmacology of conventional cytotoxic anticancer drugs.
- Understand the side effects and limitations of conventional cytotoxic drugs.
23. Principles of antineoplastic agents II
Pharmacology
- Review the molecular basis of tumour EGFR signalling and angiogenesis as pharmacological targets.
- Discuss molecular targeted anticancer drugs, including monoclonal antibodies and tyrosine kinase inhibitors, and the rationale for their use.
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